Cajun Chicken Mac and Cheese is a creamy, cheesy, and spice-kissed dish that wraps comfort and bold flavor into one mouthwatering bite. Think of tender seasoned chicken mingled with smooth, rich cheese sauce over perfectly cooked pasta—all finished with a dash of Cajun heat. It’s a dish that brings Southern charm to your dinner table, whether you’re cooking for the family or hosting friends.

What sets this recipe apart is how easily it comes together while delivering restaurant-level flavor. The Cajun seasoning adds smoky depth and warmth, while the trio of cheeses makes every forkful irresistibly creamy. Whether you make it on a cozy weeknight or for a special weekend treat, this dish always hits the spot.

Why You’ll Love This Cajun Chicken Mac and Cheese

Combines the comfort of mac and cheese with a bold Cajun twist.
Creamy and cheesy, yet full of smoky and spicy flavor.
Perfect for weeknight dinners or hearty meal prep.
A one-pan wonder if you bake it all together!
Easily adaptable to your preferred spice level.

What Kind of Cheese Should I Use?

The key to a truly luscious mac and cheese is a blend of cheeses. For this recipe, a mix of sharp cheddar, mozzarella, and Parmesan brings both meltiness and flavor depth. Sharp cheddar provides a classic bite, mozzarella brings stretch, and Parmesan adds a salty, nutty kick. Want to mix it up? Gouda, Monterey Jack, or even Pepper Jack work beautifully too.

Ingredients for the Cajun Chicken Mac and Cheese

This dish is a flavor bomb, and each ingredient plays a role in balancing richness with spice:

Chicken Breast: Lean, juicy, and perfect for soaking up Cajun seasoning.
Cajun Seasoning: Adds smoky heat and depth; you can use store-bought or homemade.
Elbow Macaroni or Cavatappi: Holds the creamy sauce well with their grooves and curves.
Butter: Forms the base of the roux, giving richness to the cheese sauce.
Flour: Helps thicken the sauce for that velvety texture.
Whole Milk & Heavy Cream: The dynamic duo for a rich, smooth base.
Sharp Cheddar Cheese: Brings that classic cheesy punch.
Mozzarella Cheese: Adds gooeyness and stretch.
Parmesan Cheese: Finishes the sauce with a savory, salty bite.
Salt & Pepper: To taste.
Fresh Parsley or Chives: Optional, for garnish and color pop.

How To Make the Cajun Chicken Mac and Cheese

Step 1: Cook the Pasta

Boil your pasta in salted water until al dente. Drain and set aside.

Step 2: Season & Cook the Chicken

Cut the chicken into bite-sized pieces. Toss with Cajun seasoning, then sear in a skillet with a little oil until golden and cooked through. Remove and set aside.

Step 3: Make the Cheese Sauce

In the same pan, melt butter and whisk in flour to make a roux. Slowly pour in milk and cream while whisking. Let it simmer until thickened, then stir in all the cheeses until melted and smooth.

Step 4: Combine Everything

Add the pasta and chicken back into the pan. Toss to coat everything in the creamy cheese sauce. Taste and adjust seasoning if needed.

Step 5: (Optional) Bake It

Transfer the mixture to a baking dish, sprinkle extra cheese on top, and bake at 375°F for 15-20 minutes until bubbly and golden.

How to Serve and Store Cajun Chicken Mac and Cheese

This hearty dish feeds 4 to 6 people generously, making it ideal for families or entertaining.

To serve, scoop generous portions into bowls and sprinkle with fresh parsley or chives. It pairs beautifully with a crisp green salad or warm cornbread.

Store any leftovers in an airtight container in the fridge for up to 4 days. To reheat, add a splash of milk and warm it slowly over the stove or microwave to revive the creamy texture.

What to Serve With Cajun Chicken Mac and Cheese?

Fresh Green Salad

A crunchy mixed salad with lemon vinaigrette balances the richness of the dish.

Garlic Bread

Because more carbs are always welcome with cheese.

Roasted Veggies

Roasted broccoli, zucchini, or bell peppers add a colorful, healthy touch.

Southern-Style Cornbread

A slightly sweet cornbread complements the Cajun spice beautifully.

Grilled Asparagus

Adds a smoky, charred contrast that works well.

Pickled Jalapeños or Red Onions

Add tangy heat and crunch if you like a little zing on the side.

Coleslaw

The creamy, tangy crunch makes for a cooling contrast.

Want More Chicken Dinner Ideas?

If this Cajun Chicken Mac and Cheese lit up your tastebuds, explore more comforting chicken-based favorites on Nora Nosh:

Chicken Cordon Bleu Casserole — a creamy and hearty twist on a French classic.
Garlic Butter Chicken with Rigatoni and Parmesan — rich, buttery, and full of garlic flavor.
Doritos Chicken Casserole — for a crunchy, bold twist on weeknight chicken.
Longhorn Parmesan Crusted Chicken — crisp and juicy with a savory topping.
Crazy Good Chicken Pasta Casserole — a family favorite with lots of creamy, cheesy goodness.

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📌 Save this recipe to your Pinterest comfort food board so it’s right there when you crave cheesy spice!

Let me know in the comments how you spiced yours up. Did you use extra cheese, or maybe throw in some andouille sausage? I love hearing your twists and tips!

Find more comfort food and family favorites on my Pinterest board: Nora Nosh Recipes.

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