Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

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There’s something utterly irresistible about a heaping plate of creamy Cajun chicken fettuccine. Rich, spicy, and cheesy in all the right ways, this dish combines tender grilled chicken breast with a silky garlic mozzarella cheese sauce that perfectly coats every strand of fettuccine. It’s a satisfying and comforting dinner that feels like a restaurant-quality meal right from your kitchen.

The Cajun seasoning brings a bold, smoky heat that contrasts beautifully with the cool creaminess of the cheese sauce. The garlic and mozzarella combo gives it a deep, mellow flavor that’s soothing and indulgent. Whether you’re cooking for a weeknight meal or a weekend gathering, this dish makes everyone at the table ask for seconds.

Why You’ll Love This Creamy Cajun Chicken Fettuccine

If you love a dish that walks the line between comfort and kick, this recipe is for you. The spice level is customizable, so it can satisfy both mild and heat-loving palates. The cream sauce is decadently cheesy yet still light enough not to overpower the other ingredients.

It’s also incredibly flexible—swap in shrimp, use gluten-free noodles, or go vegetarian by replacing chicken with roasted vegetables. Plus, it comes together in under 40 minutes, making it a strong contender for your go-to weeknight dinner.

What Kind of Fettuccine Should I Use?

Fresh fettuccine will give you a silky texture and absorb the sauce beautifully, but dried fettuccine works just as well and is more convenient for most home cooks. Choose a brand that cooks up al dente for the best bite.

If you’re feeling adventurous, try spinach or tomato fettuccine for a colorful twist that adds subtle flavor. Avoid thin pasta like angel hair—they get lost in the richness of the sauce.

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Ingredients for the Creamy Cajun Chicken Fettuccine

Each ingredient in this recipe is carefully selected to create a balanced dish with layers of flavor and texture. Here’s what you’ll need and why it matters:

• Fettuccine Pasta: A wide, flat noodle that holds creamy sauces well and provides a hearty base.
• Chicken Breast: Lean and protein-rich, it absorbs Cajun seasoning beautifully when grilled or seared.
• Cajun Seasoning: Adds a smoky, spicy, and earthy flavor that defines this dish.
• Garlic: Minced garlic infuses the sauce with a savory depth.
• Butter: Used for sautéing and to enrich the cheese sauce.
• Heavy Cream: The key to a luxurious, velvety sauce.
• Mozzarella Cheese: Melts smoothly into the sauce for a stringy, cheesy pull in every bite.
• Parmesan Cheese: Adds sharpness and umami to round out the cheesy profile.
• Olive Oil: For cooking the chicken to golden perfection.
• Parsley (optional): A fresh herbal note that brightens the final dish.

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How To Make the Creamy Cajun Chicken Fettuccine

Step 1: Cook the Fettuccine

Bring a large pot of salted water to a boil. Cook the fettuccine according to package directions until al dente. Drain and set aside, reserving about 1/2 cup of pasta water.

Step 2: Season and Cook the Chicken

Rub the chicken breasts with olive oil and generously coat them with Cajun seasoning. In a skillet over medium-high heat, sear the chicken until golden brown and fully cooked, about 6-7 minutes per side. Let it rest before slicing.

Step 3: Make the Garlic Mozzarella Cheese Sauce

In the same skillet, lower the heat and add butter. Sauté minced garlic until fragrant. Pour in the heavy cream and bring to a gentle simmer. Stir in mozzarella and Parmesan cheeses until melted and smooth.

Step 4: Combine Pasta and Sauce

Add the cooked fettuccine to the skillet with the cheese sauce. Toss to coat, using reserved pasta water to thin the sauce if needed.

Step 5: Assemble and Serve

Plate the pasta and top with sliced Cajun chicken. Sprinkle with fresh parsley and serve immediately.

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How to Serve and Store Creamy Cajun Chicken Fettuccine

This creamy Cajun chicken fettuccine is rich and filling, easily feeding 4 hungry people as a main course. Serve it hot, straight from the skillet, for the best texture and flavor.

To store leftovers, transfer to an airtight container and refrigerate for up to 3 days. Reheat gently on the stove with a splash of milk or cream to revive the sauce’s silkiness. Avoid microwaving for too long, as it may make the chicken rubbery and the sauce separate.

This dish also holds up surprisingly well for meal prep. Store the sauce separately from the pasta and chicken if possible, then combine when ready to eat.

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What to Serve With Creamy Cajun Chicken Fettuccine

Garlic Bread

The perfect companion to soak up all that creamy cheese sauce. Go with homemade or store-bought—just make sure it’s buttery and crisp.

Caesar Salad

Its crisp romaine, tangy dressing, and crunchy croutons offer a cool, refreshing contrast to the warm, creamy pasta.

Roasted Broccoli

A healthy and flavorful side that adds green to your plate and holds up to the bold Cajun spices.

Southern Cornbread

Add a touch of Southern flair. Its slightly sweet flavor complements the spice from the Cajun seasoning.

Grilled Asparagus

Lightly charred asparagus adds a grassy, earthy note that pairs well with garlic and cheese.

Creamed Spinach

For those who want to double down on creamy sides, this adds a luxurious, green component.

Chopped Wedge Salad

A wedge salad with bacon, tomato, and ranch or blue cheese can add both crunch and coolness.

Crispy Fried Zucchini

For a little indulgence, these crunchy bites make a fun and flavorful starter or side.

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Want More Pasta Ideas with a Kick?

If you love this Creamy Cajun Chicken Fettuccine, you’ll definitely want to try these other spicy, cheesy, and flavor-packed meals:

• Creamy Ground Beef Alfredo Pasta: A Comforting Indulgent Delight
• Buffalo Chicken Lasagna: A Spicy, Cheesy Twist on a Classic
• Marry Me Chicken Pasta Recipe
• Cheesesteak Tortellini in Rich Provolone Sauce
• Creamy Garlic Shrimp Pasta

These dishes are all big on bold flavor and comfort food vibes. Perfect for dinner ideas, easy recipe planning, or when you’re craving something truly satisfying.

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📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you keep it classic or throw in your own twist? Maybe extra garlic or even a splash of white wine?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook with more flavor and less fuss.

Explore beautifully curated comfort food recipes and healthy-boosting meals on NoraNosh Recipes on Pinterest and discover your new favorite dishes!

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