If you’re craving comfort with a little kick, this Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce is exactly what you need. It’s the kind of meal that combines soul-warming creaminess with the bold punch of Cajun spice. The golden seared chicken breasts are juicy and well-seasoned, sitting atop a mountain of tender rotini swirled in a garlicky, cheesy mozzarella sauce that’s impossible to resist.

Perfect for weeknight dinners or when you’re entertaining friends, this dish is big on flavor yet easy enough to whip up without fuss. The spiral rotini holds onto every bit of that rich sauce, making every bite saucy, spicy, and full of cozy indulgence.

Why You’ll Love This Creamy Cajun Chicken Rotini

Bold Cajun flavor that satisfies spice lovers.
Creamy and cheesy garlic mozzarella sauce.
Perfect for a quick dinner that feels gourmet.
Uses simple ingredients but delivers restaurant-quality taste.
Family-friendly and endlessly customizable.

What Kind of Pasta Should I Use?

Rotini is the star of this recipe for good reason. Its corkscrew shape perfectly traps the velvety garlic mozzarella sauce, ensuring every forkful is drenched in flavor. However, you can easily substitute it with penne, fusilli, or even farfalle if that’s what you have on hand. Just avoid thin noodles like spaghetti or angel hair—they can’t hold the sauce the same way.

Ingredients for the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Each ingredient in this dish plays a flavorful and functional role. From heat-packed spices to creamy cheese, here’s why each item belongs in your pot.

Rotini pasta – The spiral shape catches all the creamy sauce and delivers texture in every bite.
Chicken breasts – Sliced and seasoned, they bring protein and a juicy bite to the meal.
Olive oil – Helps sear the chicken to golden-brown perfection.
Cajun seasoning – The main flavor punch with smoky, spicy depth.
Garlic cloves – Freshly minced for bold flavor in the sauce.
Butter – Adds richness to the base of the mozzarella sauce.
All-purpose flour – Used to create a roux for thickening the sauce.
Milk – The creamy backbone of the sauce.
Mozzarella cheese – The melty, gooey element that makes the sauce luxurious.
Parsley (optional) – For a fresh finish and hint of color.
Salt & black pepper – To balance and enhance all the flavors.

How To Make the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Let’s bring it all together with these easy steps:

Step 1: Boil the Rotini

Start by cooking your rotini pasta in salted boiling water until al dente. Drain and set aside, but reserve about half a cup of pasta water.

Step 2: Season and Sear the Chicken

Rub the chicken breasts with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium-high heat. Sear the chicken on both sides until browned and cooked through. Let it rest, then slice.

Step 3: Make the Garlic Mozzarella Sauce

In the same pan, melt butter and sauté minced garlic until fragrant. Whisk in the flour to make a roux, then slowly add the milk while stirring. Let it simmer until slightly thickened.

Step 4: Melt the Cheese

Add shredded mozzarella cheese into the sauce and stir until it’s fully melted and creamy. Adjust consistency with reserved pasta water if needed.

Step 5: Combine and Serve

Toss the cooked rotini into the sauce, mixing to coat. Plate the pasta and top with sliced Cajun chicken. Garnish with parsley if desired.

How to Serve and Store Creamy Cajun Chicken Rotini

This flavorful dish is best enjoyed hot off the stove. The creamy garlic mozzarella sauce is at its silkiest when warm, making it perfect for plating straight onto bowls or plates. This recipe yields enough to feed 4 people generously, or up to 6 smaller portions.

To store leftovers, transfer them into an airtight container and refrigerate for up to 3 days. When reheating, add a splash of milk or broth to help loosen the sauce back to its original creamy consistency.

If freezing, portion out into freezer-safe containers and freeze for up to 2 months. Thaw overnight in the fridge before gently reheating on the stove.

What to Serve With Creamy Cajun Chicken Rotini?

Looking to round out your meal? Here are some delicious sides to pair with this creamy pasta dish:

Garlic Bread

Perfect for soaking up any extra sauce and adding a crunchy contrast.

Roasted Vegetables

Try oven-roasted zucchini, bell peppers, or asparagus to balance the richness.

Caesar Salad

A crisp, tangy Caesar adds freshness and crunch to every bite.

Corn on the Cob

Sweet corn complements the spiced Cajun flavors wonderfully.

Parmesan Green Beans

Lightly sauteed with garlic and cheese, they pair well with creamy pasta.

Side of Coleslaw

For a chilled, creamy crunch that contrasts nicely with warm pasta.

Crusty Artisan Bread

Thick slices of warm bread can turn this into a cozy, rustic dinner.

Lemon-Herb Cucumbers

Fresh cucumber slices with lemon juice and herbs add a refreshing bite.

Want More Pasta Ideas with a Twist?

If you love this Creamy Cajun Chicken Rotini, you’ll probably go crazy for these other bold and comforting dishes:

Garlic Butter Meatballs with Velvety Parmesan Penne: Indulgent, cheesy, and family-friendly.
Marry Me Chicken Pasta Recipe: A fan-favorite for creamy chicken pasta lovers.
Buffalo Chicken Lasagna – A Spicy, Cheesy Twist: Think buffalo wings meet pasta bake.
Beef Pasta in a Creamy Garlic Sauce: Garlic lovers rejoice in this ultra-saucy pasta.
Crazy Good Chicken Pasta Casserole: Easy, baked, and loaded with comfort.

Save This Pin For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out! Did you go extra spicy with the Cajun? Maybe you swapped in shrimp or added mushrooms? I’d love to hear how you made it your own.

Explore beautifully curated comfort food recipes on NoraNosh Recipes on Pinterest and discover your new favorite cozy dinner ideas!

Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Author: Nora
Total Time: 30 minutes
Yield: 4 servings

Print Recipe

Description

Bring bold Southern flavor to your table with this *Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce* — the perfect quick dinner idea when you want something creamy, spicy, and satisfying. Juicy Cajun-seasoned chicken rests over tender rotini pasta, all wrapped in a luscious garlic mozzarella sauce that clings to every spiral. Whether you’re craving a cozy dinner idea or looking for comfort food with a kick, this easy recipe checks all the boxes. Great for weeknights, dinner parties, or next-day leftovers. Packed with flavor, creamy texture, and dinner-ready appeal!

Instructions

1. Boil the rotini pasta in salted water until al dente. Reserve ½ cup pasta water, then drain and set aside.

2. Season the chicken breasts with Cajun seasoning, salt, and pepper.

3. In a skillet, heat olive oil over medium-high heat. Sear the chicken on both sides until fully cooked. Let rest, then slice.

4. In the same skillet, melt butter and sauté garlic until fragrant. Add flour and whisk to make a roux.

5. Slowly add milk, whisking continuously until the sauce thickens.

6. Stir in mozzarella cheese until melted and smooth. Adjust consistency with reserved pasta water if needed.

7. Toss in the cooked rotini and mix to coat evenly.

8. Serve the pasta topped with sliced chicken and optional parsley.

Notes

Use freshly grated mozzarella for best melting quality — pre-shredded can be drier.

Don’t skip reserving pasta water — it’s magic for loosening the sauce!

Prep Time: 10 minutes
Cook Time: 20 minutes
Category: Dinner
Method: Stovetop
Cuisine: Cajun Fusion

Nutrition

Serving Size: 1 plate (¼ recipe)
Calories: 580
Sugar: 4g
Sodium: 740mg
Fat: 28g
Saturated Fat: 12g
Unsaturated Fat: 14g
Trans Fat: 0g
Carbohydrates: 46g
Fiber: 2g
Protein: 39g
Cholesterol: 110mg

Keywords: creamy pasta, Cajun chicken, quick dinner, garlic mozzarella, rotini recipe