This Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is a bold and comforting dish that brings together smoky spices, juicy grilled chicken, and a luscious cheesy sauce. The spaghetti is tossed in a garlic-rich, mozzarella-infused cream that clings to every strand, creating the ultimate cozy meal with a Cajun kick.

Perfect for weeknights when you want something hearty but a little exciting, or for entertaining guests who love a little spice, this recipe delivers flavor in every bite. It’s one of those dishes where the sauce practically begs to be soaked up with crusty bread.

Why You’ll Love This Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Bold Cajun Flavor: A smoky, spicy kick that wakes up your taste buds.
Creamy, Cheesy Sauce: Silky garlic cream blended with gooey mozzarella.
Hearty & Filling: Satisfies like comfort food should, with protein and carbs in balance.
Weeknight-Friendly: Quick prep and simple steps without compromising taste.
Family-Approved: Kids and adults both go back for seconds.

What Kind of Spaghetti Should I Use?

You can use traditional spaghetti, or feel free to try angel hair for a lighter feel or fettuccine for something even more indulgent. For added nutrition, whole wheat spaghetti or even chickpea pasta works great and holds up well to the rich sauce.

What matters most is cooking the pasta just to al dente so it doesn’t go mushy when mixed with the hot sauce and chicken.

Ingredients for the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

This recipe is loaded with simple yet flavorful ingredients that come together in a magical way. Each component plays a key role in building layers of taste and texture.

Spaghetti: The base of this dish, absorbing the creamy sauce and holding the whole recipe together.
Chicken Breast: Boneless, skinless chicken breast is perfect for slicing and searing with Cajun spices for a juicy, flavorful protein.
Cajun Seasoning: The star of the show. Adds heat, smokiness, and that unmistakable Louisiana kick.
Garlic Cloves: Fresh minced garlic brings the aromatic depth that balances the creamy richness.
Butter: Used for sautéing and adds a luxurious mouthfeel to the sauce.
Heavy Cream: Creates the rich base of the sauce, making it velvety and indulgent.
Mozzarella Cheese: Melts smoothly into the cream to give it that stretchy, gooey texture everyone loves.
Parmesan Cheese: Adds a touch of nutty saltiness that enhances the sauce.
Salt and Pepper: To season and balance all the flavors.
Fresh Parsley: Optional, but adds a fresh pop of green and bright flavor to finish the dish.

How To Make the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Step 1: Cook the Spaghetti

Bring a large pot of salted water to a boil. Cook spaghetti according to the package instructions until al dente. Drain and set aside.

Step 2: Season and Sear the Chicken

Pat the chicken breasts dry and rub them with Cajun seasoning on both sides. Heat butter in a skillet over medium-high heat. Sear the chicken for 5-6 minutes per side until golden brown and cooked through. Remove from pan and let rest.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, add more butter if needed and sauté the minced garlic until fragrant. Pour in the heavy cream and bring it to a gentle simmer. Stir in the mozzarella and Parmesan cheeses. Whisk until the sauce is smooth and creamy. Season with salt and pepper to taste.

Step 4: Combine Pasta and Sauce

Add the cooked spaghetti to the skillet and toss it in the sauce until fully coated.

Step 5: Slice Chicken and Serve

Slice the rested chicken into strips and place on top of the pasta. Garnish with chopped parsley and extra Parmesan if desired. Serve immediately and enjoy that creamy Cajun goodness.

How to Serve and Store This Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

This dish is best served hot and fresh, straight from the skillet. The creamy sauce clings beautifully to the pasta while the sliced Cajun chicken rests perfectly on top, making every bite a balanced mix of spice and creaminess.

This recipe feeds about 4 hearty servings, ideal for a family dinner or for leftovers that make weekday lunches exciting.

To store, let the pasta cool completely before transferring it to an airtight container. Refrigerate for up to 3 days. When reheating, add a splash of cream or milk to loosen the sauce and stir over low heat on the stovetop or microwave in intervals.

What to Serve With Creamy Cajun Chicken Spaghetti?

Garlic Bread

The sauce begs to be scooped with buttery garlic bread. Toasty, crisp, and perfect for dipping.

Caesar Salad

A crisp, tangy Caesar salad offers a refreshing contrast to the creamy richness of the pasta.

Roasted Broccoli

Adds crunch and earthiness to balance the cheesy flavors. Plus, it’s a great way to sneak in veggies.

Cornbread Muffins

If you want to lean into the Southern flair, cornbread muffins make a fun and flavorful side.

Sauteed Green Beans

Simple and light, they bring a fresh snap and color to your plate.

Baked Zucchini Rounds

Roasted with olive oil and Parmesan, these are a crisp, savory side that doesn’t overpower.

Lemon Cucumber Water

Pair your meal with something refreshing to cool down the Cajun heat.

A Glass of White Wine

A chilled glass of Sauvignon Blanc or Pinot Grigio complements the spice and richness beautifully.

Want More Pasta Ideas with a Bold Twist?

If you love this Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce, you’re going to be obsessed with these next-level pasta creations from NoraNosh:

Creamy Garlic Shrimp Pasta when you want seafood in a luscious garlic cream.
Marry Me Chicken Pasta Recipe for another creamy dish with sun-dried tomato charm.
Creamy Beef and Shells for a hearty one-pan comfort meal.
Garlic Butter Shrimp Scampi Lasagna if you’re craving garlicky layers of indulgence.
Cheesesteak Tortellini in Rich Provolone Sauce when you want pasta loaded with bold, cheesy steakhouse vibes.

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And let me know in the comments how yours turned out! Did you go heavy on the Cajun spice or keep it mild? Did you try it with shrimp or a different cheese?

I love hearing how you all personalize these recipes. Questions are welcome too—let’s cook smarter together.

Explore beautifully curated comfort dishes, cozy dinners, and health-boosting drinks on NoraNosh Recipes on Pinterest and find your new favorite meal inspiration!

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Author: Nora
Total Time: 30 minutes
Yield: 4 servings

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Description

If you’re looking for a recipe that fuses comforting creaminess with bold Southern heat, this Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce will hit every craving. Tender Cajun-spiced chicken rests on a bed of spaghetti smothered in a silky garlic mozzarella sauce that’s rich, satisfying, and perfect for both weeknight dinners and entertaining guests. Whether you’re after quick dinner ideas, a creamy chicken pasta recipe, or simply craving something cozy and easy to make, this dish delivers comfort and flavor in every bite.